Sehlopha sa rona sa pharmacokinetic se sebetsa ka ho khetheha ho nts'etsopele ea preclinical, tlhahlobo ea DMPK le ngoliso ea IND. Re thehile sethala se kopaneng sa in vitro & in vivo screening technology ho ts'ehetsa ho sibolloa le nts'etsopele ea lithethefatsi. Caerulum Pharma e fana ka litšebeletso tse feto-fetohang le tse etselitsoeng motho ka mong bakeng sa tharollo ea DMPK e sebetsang hantle le e theko e tlaase ho ntšetsa pele lipatlisiso tsa hau.
1.Likarolo tsa thuto
Limolek'hule tse nyane, lihlahisoa tsa tlhaho, polypeptides.
2.Litšebeletso tse teng
Tekolo e tlamang protheine ea plasma/lisele
Karolelano ea plasma ho mali
Sebete sa microsomal metabolic botsitso
Ho tsitsa koloing le plasma
Boitsebiso ba metabolite
Phenotyping ea karabelo ea CYP
Thibelo ea CYP
3.Kahong
Ho kenngoa ha Hepatocyte
Caco-2 Permeability
Phenotyping ea karabelo ea UGT