in vitro Pharmacokinetic Assays

Sehlopha sa rona sa pharmacokinetic se sebetsa ka ho khetheha ho nts'etsopele ea preclinical, tlhahlobo ea DMPK le ngoliso ea IND. Re thehile sethala se kopaneng sa in vitro & in vivo screening technology ho ts'ehetsa ho sibolloa le nts'etsopele ea lithethefatsi. Caerulum Pharma e fana ka litšebeletso tse feto-fetohang le tse etselitsoeng motho ka mong bakeng sa tharollo ea DMPK e sebetsang hantle le e theko e tlaase ho ntšetsa pele lipatlisiso tsa hau.

1.Likarolo tsa thuto

Limolek'hule tse nyane, lihlahisoa tsa tlhaho, polypeptides.

2.Litšebeletso tse teng

Tekolo e tlamang protheine ea plasma/lisele

Karolelano ea plasma ho mali

Sebete sa microsomal metabolic botsitso

Ho tsitsa koloing le plasma

Boitsebiso ba metabolite

Phenotyping ea karabelo ea CYP

Thibelo ea CYP

3.Kahong

Ho kenngoa ha Hepatocyte

Caco-2 Permeability

Phenotyping ea karabelo ea UGT


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