ND-630
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 10mg | E teng thepeng e teng ka lebenkeleng | 300 |
| 50mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 100mg | E teng thepeng e teng ka lebenkeleng | 800 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl) -2-methylpropanamide
SMILES Khouto:
O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O
Khoutu ea InChi:
InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20(3 9-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10, 12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
InChi Key:
ZZWXIBKLBMSCS-FQEVSTJZSA-N
Keyword:
ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
ND-630 e thibela hACC1 (IC50=2.1±0.2 nM) le hACC2 (IC50=6.1±0.8 nM). Thibelo e ka khutlisetsoa morao 'me e totobetse haholo bakeng sa ACC. ND-630 e thibela mosebetsi oa ACC ka ho sebelisana ka hare ho phosphopeptide-acceptor le sebaka sa dimerization sa enzyme ho thibela dimerization. ND-630 e thibela motsoako oa acid e mafura ka EC50 ea 66 nM liseleng tsa HepG2 ntle le ho fetola palo eohle ea lisele, mahloriso a protheine ea cellular, le ho kenngoa ha acetate ka k'holeseterole[1].
Sepheo: ACC
