Vactosertib
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 500mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1300 |
| 5g | E teng thepeng e teng ka lebenkeleng | 3800 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
N-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl )-2-fluoroaniline
SMILES Khouto:
FC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2
Khoutu ea InChi:
InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28- 19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
InChi Key:
FJCDSQATIJKQKA-UHFFFAOYSA-N
Keyword:
Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)
Tlhaloso:
Vactosertib, eo hape e tsejoang e le EW-7197 ke inhibitor e matla ea ALK5. EW-7197 e bonts'itse ts'ebetso e matla ea anti-metastatic in vivo, e bonts'ang bokhoni ba eona ba ho sebelisoa joalo ka kalafo e khahlanong le mofets'e. EW-7197 e thibela pontšo ea TGF-β/Smad. EW-7197 e hlakola TGF-β1 e bakoang ke ho falla ha lisele tsa tumor le ho hlasela. EW-7197 e thibela metastase ea mofetše oa matsoele matšoafong.EW-7197 e lelefatsa nako ea bophelo ea BALB/c 4T1 litoeba ka ho thibela EMT. EW-7197 e thibela metastasis le ho ntlafatsa ts'ebetso ea li-cytotoxic T lymphocytes (CTLs) ho litoeba tsa 4T1 tse hlomathiselelitsoeng orthotopic.
Sepheo: ALK
