GLPG0187

Chemical Name:

(S)-3-((2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4- yl)amino) -2-((4-methoxyphenyl)sulfonamido)propanoic acid

SMILES Kodhi:

O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5)=O

InChi Code:

InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23) 32-19(2)33-28(18)36-15-12-20(13) -16-36)24-11-6-21-5-4-14-30-27(21)34-24/h6-11,20,25,35H,4-5,12-17H2,1-3H3 ,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0/s1

InChi Key:

CXHCNOMGODVIKB-VWLOTQADSA-N

Keyword:

GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).

Tsanangudzo:

Muchiyero chakasimba, GLPG0187 inoratidza kusarudzwa kune akati wandei RGD integrin receptors ane IC50s ye1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM ye αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, uye αvβ8, uye αvβ8, uye. GLPG0187 inhibitor ine simba ye osteoclastic bone resorption uye angiogenesis. Kurapa neGLPG0187 dose-zvichienderana kunowedzera E-cadherin/vimentin ratio, zvichiita kuti masero ave epithelial, sessile phenotype. GLPG0187 dose-zvichienderana inoderedza saizi yealdehyde dehydrogenase yakakwira subpopulation yekenza yeprostate cancer [1]. Kurapwa kweGLPG0187 kunoguma nekutenderedza masero uye kudhumhana. GLPG0187 inoratidza dhigirii-inotsamira kwakakosha kuderedzwa kwe tumor cell migration. GLPG0187 pane zvese zvakasungwa zvinoderedza zvakanyanya kuwanda kwesero [2].

Chinangwa: αvβ1