ND-630
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 10mg | Mudura | 300 |
| 50mg | Mudura | 500 |
| 100mg | Mudura | 800 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl) -2-methylpropanamide
SMILES Kodhi:
O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O
InChi Code:
InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20(3 9-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10, 12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
InChi Key:
ZZWWXIBKLBMSCS-FQEVSTJZSA-N
Keyword:
ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).
Tsanangudzo:
ND-630 inhibits hACC1 (IC50=2.1±0.2 nM) uye hACC2 (IC50=6.1±0.8 nM). Inhibition inodzoreredzwa uye yakanyanya kurongeka kune ACC. ND-630 inhibits ACC basa kuburikidza nekubatana mukati me phosphopeptide-kugamuchira uye dimerization site ye enzyme kudzivirira dimerization. ND-630 inhibits fatty acid synthesis neEC50 ye66 nM muHepG2 masero pasina kushandura nhamba yesero, masero eprotein concentration, uye kuiswa kweacetate mucholesterol[1].
Chinangwa: ACC
