BLU-285
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 1g | Mudura | 900 |
| 5g | Mudura | 3600 |
| 10g | Mudura | 6200 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4 ]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine
SMILES Kodhi:
CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@]](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC= N3)=C2)=C1
InChi Code:
InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35( 8-10-36)2 4-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2, 1-2H3/t26-/m0/s1
InChi Key:
DWYRIWUZIJHQKQ-SANMLTNESA-N
Keyword:
BLU-285, BLU 285, BLU285, Avapritinib
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).
Tsanangudzo:
Avapritinib (BLU-285) yakaratidza biochemical in vitro chiitiko paKIT exon 17 mutant enzyme, KIT D816V (IC50=0.27 nM). Kuitwa kwemaserura eAvapritinib paKIT D816 mutants inoyerwa ne autophosphorylation mu human mast cell leukemia cell line HMC1.2, uye P815 mouse mastocytoma cell line ine IC50=4 uye 22 nM, zvichiteerana. MuKasumi-1 maseru, pa(8;21) -positive AML cell line ine KIT exon 17 N822K mutation, Avapritinib inhibits KIT N822K mutant autophosphorylation (IC50=40 nM), kudzika pasi, pamwe nekuwanda kwemasero (IC50= 75 nM)[1].
Chinangwa: KIT
