BLU-9931
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 100mg | Mudura | 220 |
| 300mg | Mudura | 500 |
| 1g | Mudura | 1350 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide
SMILES Kodhi:
C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O
InChi Code:
InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10- 17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33 )(H,29,31,32)
InChi Key:
TXEBNKKOLVBTFK-UHFFFAOYSA-N
Keyword:
BLU-9931, BLU9931, BLU 9931, 1538604-68-0
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).
Tsanangudzo:
MuMDA-MB-453 masero, BLU9931 inodzivirira zvakanyanya phosphorylation yeFGFR4 nzira yechiratidzo. BLU9931 inodzivisa kuwanda kwemitsara yemasero eHCC anoratidza chimiro cheFGFR4 chakasimba, senge Hep 3B, HUH-7, uye JHH-7 cell mitsara, ine EC50 ye<1 μM. BLU9931 inodzivirirawo kuwanda muPDX-yakatorwa sero mitsara ine isina kujeka FGFR4 nzira yekusaina [1]. BLU9931 induces bundu shrinkage muhepatocellular carcinoma modhi inoratidza inoshanda ligand/receptor complex inosanganisira FGF19/FGFR4/KLB uye inowedzera kune inokura runyorwa rwevanorwisa-FGFR4 vamiririri [2].
Chinangwa: FGFR4
