ARS-1630

Chemical Name:

(R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

SMILES Kodhi:

"C=CC(N1CCN(C2=C3C=C(Cl)[C@@]([C@@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1 )=O.[R]

InChi Code:

InChi Key:

Keyword:

ARS1630, ARS 1630, ARS-1630, 1698055-86-5

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi)

Tsanangudzo:

ARS-1630 ndiyo R-conformational atropisomer yeARS-1620, 1,000-yakapetwa ine simba pane ARS-1620 (1.2 ± 0.6 M-1s-1) uye nokudaro inoita seyakasiyana isingashande yekudzora komisheni.

Chinangwa: KRAS (K-Ras G12C)