E-7046

Chemical Name:

(S)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid

SMILES Kodhi:

O=C(O)C1=CC=C([C@@H](NC(C2=C(OC3=CC=CC(C(F)(F)F)=C3)N(C)N=C2C (F)F)=O)C)C=C1

InChi Code:

InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30( 2)20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H, 32,33)/t11-/m0/s1

InChi Key:

MKLKAQMPKHNQPR-NSHDSACASA-N

Keyword:

E-7046, E7046, E 7046, 1369489-71-3

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).

Tsanangudzo:

Mune iyo CT-26 tumor modhi, iyo E7046/RT musanganiswa inokonzera anti-bundu ndangariro mhinduro ye9 mhuka. Muiyo 4T1 modhi, musanganiswa weE7046 uye RT zvakare unoburitsa akakosha ari nani bundu kukura basa rekudzivirira zvichienzaniswa nekurapa kwega kwega. Iko kusanganiswa kunovandudza kupona nekudzivisa kunotevera kwepapupo metastasis ye4T1 tumors [1]. E7046 (150 mg/kg) inodzivisa kukura kweakawanda syngeneic bundu modhi. Kuvharwa kwe EP4 kusaina kunosimudzira anti-tumor DC kusiyanisa uye kunonotsa bundu kukura mumakonzo. Kurapa kweE7046 kunoderedza kukura kana kurambwa kwemamota akaiswa mu vivo nenzira inotsamira pane ese myeloid uye CD8C T masero. Uyezve, kutonga pamwe chete kweE7046 uye E7777, IL-2-diphtheria toxin fusion protein iyo inonyanya kuuraya Tregs, synergistically inovhiringidza myeloid uye Treg immunosuppressive network, zvichiita kuti ibudirire uye inogara yakasimba anti-tumor immune immune mumamouse tumormodels [2] .

Chinangwa: EP4