TH-302; Evofosfamide
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 100mg | Mudura | 360 |
| 1g | Mudura | 1000 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
SMILES Kodhi:
O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C
InChi Code:
InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)
InChi Key:
UGJWRPJDTDGERK-UHFFFAOYSA-N
Keyword:
TH-302, TH302, TH 302, Evofosfamide, 918633-87-1
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi)
Tsanangudzo:
Evofosfamide, inozivikanwawo seTH-302, inonzi hypoxia-activated prodrug inosanganisira 2-nitroimidazole phosphoramidate conjugate ine inogona kuita antineoplastic chiitiko. Iyo 2-nitroimidazole moiety ye hypoxia-activated prodrug TH-302 inoshanda se hypoxic trigger, ichibudisa DNA-alkylating dibromo isophosphoramide mustard moiety mukati me hypoxic regions of tumors. Normoxic tishu inogona kuchengetedzwa nekuda kweiyo hypoxia-chaiyo chiitiko chemumiriri uyu, zvichigona kuderedza systemic toxicity. Tarisa uone kushanda kwekiriniki miedzo kana kuvharwa kwekiriniki miedzo uchishandisa mumiririri uyu. (NCI).
Chinangwa: DNA Alkylating Agent
