SEL120-34A
Fa'amatalaga Oloa
Faailoga o oloa
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Igoa vaila'au:
7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline Hydrochloride
SMILES Code:
CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl
InChi Code:
InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20;/h18H,2-8H2,1H3;1H
InChi Key:
GQXLWUCQESKBSC-UHFFFAOYSA-N
upu autu:
SEL120-34A; SEL 120-34A; SEL-120-34A; SEL12034A; SEL 12034A; SEL-12034A
Solubility:
Teuina:
Fa'amatalaga:
SEL120-34A o le malosi ma le filifilia CDK8 inhibitor o loʻo galue i sela AML ma maualuga maualuga o serine phosphorylation o STAT1 ma STAT5 transactivation domains. O le EL120-34A e taofia ai le phosphorylation o STAT1 S727 ma STAT5 S726 i sela o le kanesa in vitro. E le gata i lea, o tulafono faatonutonu o STATs- ma le NUP98-HOXA9-faʻalagolago transcription ua matauina o se faiga faʻapitoa o gaioiga i vivo.
Sini: CDK8
