LDC000067

Igoa vaila'au:

3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide

SMILES Code:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

InChi Code:

InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13( 9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

InChi Key:

GGQCIOOSELPMBB-UHFFFAOYSA-N

upu autu:

LDC000067; LDC-000067; LDC 000067

Solubility: 

Teuina: 

Fa'amatalaga:

LDC000067 ose malosi ma filifili CDK9 inhibitor. LDC000067 faʻasaina in vitro transcription i se ATP-faʻatauva ma faʻalagolago i fua. O faʻamatalaga faʻamatalaga faʻamatalaga o sela na togafitia i le LDC000067 na faʻaalia ai se faʻaitiitiga filifilia o mRNA pupuu, e aofia ai faʻatonuga taua o le faʻateleina ma apoptosis. O le su'esu'ega o le de novo RNA synthesis na fa'ailoa mai ai se tulaga lelei tele o le CDK9. I le molecular ma le cellular level, LDC000067 toe gaosia aafiaga uiga o le CDK9 inhibition e pei o le faʻaleleia o le taofi o le RNA polymerase II i genes ma, sili ona taua, faʻaosoina o apoptosis i sela o le kanesa. LDC000067 faʻalavelave P-TEFb-faʻalagolago i le faʻaliliuga in vitro. Fa'aoso apoptosis in vitro ma in vivo fa'atasi ma BI 894999.

Sini: CDK9