Alvocidib

Igoa vaila'au:

2-(2-chlorophenyl) -5,7-dihydroxy-8-((3R,4S) -3-hydroxy-1-methylpiperidin-4-yl) -4H-chromen-4-one

SMILES Code:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

InChi Code:

InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(28-21) 19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17 +/m1/s1

InChi Key:

BIIVYFLTOXDAOV-PXAZEXFGSA-N

upu autu:

L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib

Solubility: 

Teuina: 

Fa'amatalaga:

Alvocidib o le N-methylpiperidinyl chlorophenyl flavone fa'afefiloi. I le avea ai o se inhibitor o le cyclin-dependent kinase, alvocidib faʻaosofia le puʻeina o le taamilosaga e ala i le puipuia o le phosphorylation o cyclin-dependent kinases (CDKs) ma e ala i le faʻatonutonuina o le cyclin D1 ma le D3 faʻamatalaga, e mafua ai le G1 cell cycle puʻeina ma apoptosis. O lenei sooupu o se faʻatauvaʻa faʻatauvaʻa o gaioiga adenosine triphosphate. Siaki mo faʻataʻitaʻiga faʻapitoa faʻataʻitaʻiga poʻo faʻataʻitaʻiga tapuni faʻataʻitaʻiga e faʻaaoga ai lenei sooupu.

Sini: CDK