Adavivint
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 100mg | E tele | 500 |
| 500mg | E tele | 800 |
| 1g | E tele | 1200 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
N-(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}pyridin-3-yl)-3 -methylbutanamide
SMILES Code:
CC(C)CC(NC1=CC(C2=CC3=C(NN=C3C(N4)=NC5=C4C(C6=CC=CC(F)=C6)=CN=C5)C=C2)=CN= C1)=O
InChi Code:
InChI=1S/C29H24FN7O/c1-16(2)8-26(38)33-21-10-19(12-31-13-21)17-6-7-24-22(11-17)28( 37-36-24)29-34 -25-15-32-14-23(27(25)35-29)18-4-3-5-20(30)9-18/h3-7,9-16H,8H2,1-2H3,( H,33,38)(H,34,35)(H,36,37)
InChi Key:
AQDWDWAYVBQMAM-UHFFFAOYSA-N
upu autu:
Adavivint, SM04690, SM-04690, SM 04690, 1467093-03-3
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
O se mea fou mole mole mole Wnt inhibitor ala ma EC50 o le 3 nM in vitro; fa'aosofia le eseesega o le hMSC i le matua, chondrocytes galue ma fa'aitiitia le maualuga o fa'ailoga catabolic cartilage; fa'alelei fa'alelei le Osteoarthritis Research Society International (OARSI) fa'asologa o tala fa'asolopito ma biomarkers i se fa'ata'ita'iga OA rodent.
Sini: WNT
