AZD-5069

Igoa vaila'au:

N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide

SMILES Code:

O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O

InChi Code:

InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2, 1H3,(H,21,22,23)/t11-,14+/m1/s1

InChi Key:

QZECRCLSIGFCIO-RISCZKNCSA-N

upu autu:

AZD-5069, AZD5069, AZD 5069, 878385-84-3

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

AZD-5069 o se faʻalavelave malosi ma filifilia CXCR2 faʻatasi ma le gafatia e faʻalavelave ai le femalagaiga o neutrophil i luga o le ea i tagata mamaʻi ma le COPD. O le AZD-5069 na faʻaalia e taofia ai le fusifusia o le CXCL8 faʻasalalau i le tagata CXCR2 ma le pIC50 tau o le 9.1. E le gata i lea, o le AZD5069 na faʻalavelaveina le neutrophil chemotaxis, faʻatasi ai ma le pA2 e tusa ma le 9.6, ma faʻamatalaga mole faʻapipiʻi, ma le pA2 o le 6.9, i le tali atu i le CXCL1. O le AZD5069 o se faʻalavelave faʻafefe malie o le CXCR2 faʻatasi ai ma aʻafiaga o le taimi ma le vevela o loʻo faʻaalia i luga o vailaʻau faʻafomaʻi ma kinetics fusifusia. AZD-5069 e mafai foi ona aoga mo tagata maʻi i tulaga inflammatory.

Sini: CXCR2