GDC-0077
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 100mg | E tele | 500 |
| 500mg | E tele | 800 |
| 1g | E tele | 1200 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
(S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)amino)propanamide
SMILES Code:
C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1
InChi Code:
InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11) 24)2 5-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26 )/t9-,12-/m0/s1
InChi Key:
SGEUNORSOZVTOL-CABZTGLSA-N
upu autu:
GDC-0077, GDC0077, GDC 0077, 2060571-02-8
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
O le GDC-0077 o se fa'aitaga PI3K e avanoa tautala ma filifili (IC50 = 0.038 + 0.003 nM) fa'atasi ai ma> 300-filifili filifilia i luga o isi Vasega I PI3K isoforms. GDC-0077 faʻatino lana gaioiga e ala i le fusifusia i le ATP faʻapipiʻi nofoaga o le PI3K, ma faʻafefe ai le phosphorylation o le PIP2 i le PIP3.
Sini: PI3K
