EED226

Igoa vaila'au:

N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

SMILES Code:

O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O

InChi Code:

InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22) 18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)

InChi Key:

DYIRSNMPIZZNBK-UHFFFAOYSA-N

upu autu:

EED226, EED-226, EED 226, 2083627-02-3

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

O le EED226 o se mea e sili atu le malosi, lelei ma le filifilia o le EZH2 ma le EZH1 suʻesuʻeina e faʻatatau i le tele o faʻamoemoega epigenetic ma non-epigenetic. E fa'aitiitia ai le fa'ailoga H3K27Me3 i le lalolagi atoa i sela ma fa'aalia ai ni a'afiaga e fasiotia ai sela i sela o lo'o iai se suiga Y641N heterozygous. EED226 o loʻo i ai le faʻaogaina lelei e pei ona fuaina i le Caco-2 sela i le A → B = 3.0x10-6 cm / s, faʻatasi ai ma le fua faatatau o le efflux i le 7.6 [1].

Sini: EED226