BLU-285
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 1g | E tele | 900 |
| 5g | E tele | 3600 |
| 10g | E tele | 6200 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4] ] triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl) etana-1-amine
SMILES Code:
CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@))(C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC= N3)=C2)=C1
InChi Code:
InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35( 8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H, 7-10,28H2,1-2H3/t26-/m0/s1
InChi Key:
DWYRIWUZIJHQKQ-SANMLTNESA-N
upu autu:
BLU-285, BLU 285, BLU285, Avapritinib
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
Avapritinib (BLU-285) ua faʻaalia le biochemical in vitro gaioiga i le KIT exon 17 mutant enzyme, KIT D816V (IC50=0.27 nM). Gaoioiga feaveai o Avapritinib i KIT D816 mutants e fuaina i le autophosphorylation i le mast cell leukemia cell line HMC1.2, ma le P815 mouse mastocytoma cell line ma IC50=4 ma 22 nM, faasologa. I sela Kasumi-1, i (8; 21) -positive AML cell line ma le KIT exon 17 N822K mutation, Avapritinib potently inhibits KIT N822K mutant autophosphorylation (IC50=40 nM), downstream signaling, faʻapea foʻi ma le faʻalauteleina o le telefoni (IC50=). 75 nM)[1].
Sini: KIT
