Tropifexor
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 100mg | E tele | 800 |
| 1g | E tele | 1850 |
| 5g | E tele | 7400 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8- yl) -4-fluorobenzo[d]thiazole-6-carboxylic acid
SMILES Code:
FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C( C(O)=O)C=C7S6)[C@H](CC5)C4
InChi Code:
InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12- 18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31, 32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
InChi Key:
VYLOOGHLKSNNEK-PIIMJCKOSA-N
upu autu:
Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
Tropifexor (compound 1) o se tala ma sili ona malosi agonist o le FXR ma le EC50 o le 0.2 nM. O le faʻamalosia malosi o genes BSEP ma SHP o loʻo matauina i sela muamua e Tropifexor i se faʻatonuga faʻalagolago. O le BSEP induction i luga aʻe o le taʻavale (DMSO) o loʻo matauina i faʻatonuga e maualalo ifo i le 1 nM, ae o le malosi malosi o le SHP (15-fold i luga aʻe o le taʻavale) o loʻo matauina i le 10 nM ma le faʻaogaina o le SHP i le 1 nM (3-fold) [1 ].
Sini: FXR
