Poziotinib
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 1g | Zilipo | 790 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
1-(4-((4-(3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one
SMILES Kodi:
C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O
InChi kodi:
InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27- 12-28-23 (14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27 , 28, 29)
InChi Key:
LPFWVDIFUFFKJU-UHFFFAOYSA-N
Mawu ofunika:
Poziotinib, HM-781-36, HM-781-36B, NOV-1201,NOV-120101, 1092364-38-9
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)
Kufotokozera:
Poziotinib ndi inhibitor yamphamvu ya EGFR family kinases ndi IC50 values of 3.2, 5.3, 23.5, 4.2, and 2.2 nM for wild-type EGFR, HER2, HER4, EGFRT790M, ndi EGFRL858R/T790M, motero. Ili ndi kusankha kopitilira 100 mpaka 1,000 kwa EGFR kinases pa 30 kinase ina yoyesedwa mu vitro. Poziotinib imalepheretsa kukula kwamtundu wakutchire komanso wosinthika wa EGFR kinase-odalira mapapo, m'mawere, ndi ma cell a khansa ya m'mimba (GI50s = 0.6-5.7 nM) ndikuletsa phosphorylation ya EGFR ndikupangitsa apoptosis mu vitro. Mu vivo, poziotinib imachepetsa kukula kwa chotupa mu mtundu wa HCC827 wopanda khansa ya m'mapapo ya mbewa xenograft. Mapangidwe okhala ndi poziotinib akufufuzidwa m'mayesero azachipatala ochizira EGFR-mutant lung adenocarcinoma.
Cholinga: EGFR
