Quizartinib; AC-010220; AC-220
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 5g | Zilipo | 1000 |
| 10g pa | Zilipo | 1500 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl ]phenyl} urea
SMILES Kodi:
O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C)(C)C)=C6
InChi kodi:
InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
InChi Key:
CVWXJKQAOSCOAB-UHFFFAOYSA-N
Mawu ofunika:
Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)
Kufotokozera:
Quizartinib ndi inhibitor ya tyrosine kinase 3 yokhudzana ndi FMS (FLT3; Kd = 1.6 nM) ndipo imasonyeza kusankhidwa kwakukulu kwa FLT3 poyesedwa ndi gulu la 227 kinases. Imalepheretsa kuchuluka kwa maselo a khansa ya m'magazi a anthu a MV4-11, omwe amakhala ndi kusintha kwa homozygous FLT3-ITD, ndi IC50 mtengo wa 0.56 nM.1 Pa 1 mg/kg/tsiku, quizartinib yasonyezedwa kuti ikulitsa moyo mu mbewa. chitsanzo cha FLT3-ITD acute myeloid leukemia ndi kuthetsa zotupa mu chitsanzo cha FLT3 chodalira mbewa xenograft pa 10 mg/kg.
Zolinga: FLT3
