Derazantinib; Chithunzi cha ARQ-087
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 10 mg pa | Zilipo | 800 |
| 100 mg | Zilipo | 1200 |
| 500 mg | Zilipo | 1800 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine
SMILES Kodi:
COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1
InChi kodi:
InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24- 10-4-5-12-2 7(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H ,32,33,34)/t26-/m1/s1
InChi Key:
KPJDVVCDVBFRMU-AREMUKBSSA-N
Mawu ofunika:
Derazantinib, ARQ-087, ARQ087, ARQ 087, 1234356-69-4
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
Derazantinib, yomwe imadziwikanso kuti ARQ-087, ndi inhibitor yapakamwa ya bioavailable ya fibroblast growth factor receptor (FGFR) yokhala ndi zochita za antiineoplastic. FGFR inhibitor ARQ 087 imamangiriza ndikuletsa mwamphamvu ntchito ya FGFR subtypes 1, 2 ndi 3. Izi zingapangitse kuletsa kwa FGFR-mediated transduction pathways, chotupa cell proliferation, chotupa angiogenesis ndi chotupa cell imfa mu FGFR-overexpressing maselo zotupa. . FGFR, receptor tyrosine kinase, imayendetsedwa m'mitundu yambiri yama cell chotupa ndipo imagwira ntchito yofunika kwambiri pakufalikira kwa ma cell, kusiyanitsa, angiogenesis ndi kupulumuka.
Zolinga: FGFR
