EED226
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 25 mg pa | Zilipo | 300 |
| 50 mg pa | Zilipo | 500 |
| 100 mg | Zilipo | 800 |
Dzina la Chemical:
N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
SMILES Kodi:
O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O
InChi kodi:
InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-1 1-20-21-16(15)22)18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)
InChi Key:
DYIRSNMPIZZNBK-UHFFFAOYSA-N
Mawu ofunika:
EED226, EED-226, EED 226, 2083627-02-3
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
EED226 ndi choletsa champhamvu kwambiri, chothandiza komanso chosankha cha EZH2 ndi EZH1 chowunikidwa motsutsana ndi zolinga zambiri za epigenetic ndi zomwe si za epigenetic. Zimachepetsa kwambiri chizindikiro cha H3K27Me3 padziko lonse lapansi m'maselo ndikuwonetsa zotsatira zakupha maselo m'maselo omwe ali ndi kusintha kwa heterozygous Y641N. EED226 ili ndi kupenya kwapakati monga momwe amayezera m'maselo a Caco-2 pa A→ B=3.0x10-6 cm/s, ndi chiŵerengero cha efflux pa 7.6[1].
Zolinga: EED226
