BLU-285
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 1g | Zilipo | 900 |
| 5g | Zilipo | 3600 |
| 10g pa | Zilipo | 6200 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(S) -1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4 ]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine
SMILES Kodi:
CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@]](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC= N3)=C2)=C1
InChi kodi:
InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35( 8-10-36)2 4-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2, 1-2H3/t26-/m0/s1
InChi Key:
DWYRIWUZIJHQKQ-SANMLTNESA-N
Mawu ofunika:
BLU-285, BLU 285, BLU285, Avapritinib
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
Avapritinib (BLU-285) yawonetsa zochitika za biochemical in vitro pa KIT exon 17 mutant enzyme, KIT D816V (IC50=0.27 nM). Ma cell a Avapritinib pa KIT D816 mutants amayezedwa ndi autophosphorylation mu cell mast cell leukemia cell line HMC1.2, ndi P815 mouse mastocytoma cell line ndi IC50=4 ndi 22 nM, motsatana. M'maselo a Kasumi-1, pa(8;21) -positive AML cell line yokhala ndi KIT exon 17 N822K mutation, Avapritinib imaletsa mwamphamvu KIT N822K mutant autophosphorylation (IC50=40 nM), siginecha yakumunsi, komanso kuchuluka kwa ma cell (IC50= 75 nM [1].
Cholinga: KIT
