BLU-9931
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 220 |
| 300 mg | Zilipo | 500 |
| 1g | Zilipo | 1350 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide
SMILES Kodi:
C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O
InChi kodi:
InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10- 17 (16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33) (H,29,31,32)
InChi Key:
TXEBNKKOLVBTFK-UHFFFAOYSA-N
Mawu ofunika:
BLU-9931, BLU9931, BLU 9931, 1538604-68-0
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
M'maselo a MDA-MB-453, BLU9931 imalepheretsa mwamphamvu phosphorylation ya FGFR4 njira yowonetsera. BLU9931 imalepheretsa kuchuluka kwa ma cell a HCC omwe amawonetsa mawonekedwe osasinthika a FGFR4, monga Hep 3B, HUH-7, ndi ma cell a JHH-7, okhala ndi EC50 ya<1 μM. BLU9931 imalepheretsanso kuchulukana kwa ma cell opangidwa ndi PDX okhala ndi njira yowonetsera ya FGFR4 [1]. BLU9931 imapangitsa kuchepa kwa chotupa mumitundu ya hepatocellular carcinoma yomwe imawonetsa ligand / receptor complex yomwe ili ndi FGF19/FGFR4/KLB ndikuwonjezera mndandanda womwe ukukula wa anti-FGFR4 othandizira [2].
Zolinga: FGFR4
