GDC-0326

Ingoa matū:

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)oxy)propanamide

Waehere SMILES:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

Waehere InChi:

InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3)17( 20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1

Kī InChi:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Kupumatua:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)

Whakaahuatanga:

Ko te GDC-0326 he kaitautoko kaha me te whiriwhiri i te α-Isoform o Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). Ko te GDC-0326 ka eke ki te taumata teitei o te whiriwhiringa i runga i etahi atu kinase. Ko te GDC-0326 he iti te plasma CL i roto i te tangata. I roto i te whanau PI3 kinase, e wha nga karaehe I PI3K isoforms (α, β, δ, me γ). O enei momo ahua, ko te PI3Kα te mea e pa ana ki nga mate pukupuku.

Whāinga: PI3K