AZD8186

Ingoa matū:

(R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

Waehere SMILES:

O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1

Waehere InChi:

InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20- 21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1

Kī InChi:

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Kupumatua:

AZD8186, AZD-8186, AZD 8186, 1627494-13-6

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)

Whakaahuatanga:

Ko te AZD8186 me te aukati o te beta isoform o te phosphoinositide-3 kinase (PI3K), me te mahi antineoplastic pea. I runga i te whakahaerenga, ko te PI3Kbeta inhibitor AZD8186 te aukati i te mahi a PI3Kbeta i roto i te huarahi tohu tohu PI3K/Akt/mTOR, tera pea ka heke te pikinga o te tipu o te pukupuku. Ka whakaawe hoki i te mate o te pūtau i roto i te PI3K-whakapuaki pūtau mate pukupuku. Ma te aro motuhake ki te karaehe I PI3K beta, ka kaha ake pea tenei kaihoko me te iti ake o te paitini atu i nga aukati pan PI3K. Ko te tohu PI3K-takawaenga he maha nga wa e whakahekehia ana i roto i nga pūtau mate pukupuku me te whai waahi ki te whakanui ake i te tipu o te pūtau puku, te oranga, me te aukati pukupuku ki nga momo antineoplastic. Ko AZD8186 kei raro i nga whakamatautau haumanu Wāhanga I.

Whāinga: PI3K