LX-2761

Ingoa matū:

N-(1-((2-(Dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R, 5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-butanamide

Waehere SMILES:

O=C(NC(C)(C)C(NCCN(C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@ H](O)[C@H](O)[C@@H](SC)O3)=CC=C2C)C=C1

Waehere InChi:

InChI=1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22- 13-11-21(12-14-22)8-7-9-25(36)3 4-32(2,3)31(40)33-16-17-35(4)5/h10-15,19,26-30,37-39H,7-9, 16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30-/m1/s1

Kī InChi:

BNPZTRDIESRGTC-IXYVTWBDSA-N

Kupumatua:

LX-2761, LX2761, LX 2761, 1610954-97-6

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te LX2761 he aukati SGLT1 mahi a-rohe e tino kaha ana i roto i te vitro me te whakaroa i te whakauru huka intestinal i roto i te vivo hei whakapai ake i te mana glycemic. LX2761 he hSGLt1 2.2 nM; hSGLT2 2.7 nM me F% =<2. Ko te LX2761 he ngota ngota tino kaha, matū e mau ana, me te whakawhāiti i te marama i tutuki te tohu o te ariā i roto i te OGTT i nga pota iti rawa. I hangaia te LX2761 kia noho tonu ki roto i te whekau i muri i te tuku-waha ki te aukati i te SGLT1 i te rohe me te kore e pa ki te tikanga SGLT1/2 i roto i te whatukuhu.

Whāinga: SGLT1