AZD-5069

Ingoa matū:

N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide

Waehere SMILES:

O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O

Waehere InChi:

InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-1 0-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2,1H3,(H ,21,22,23)/t11-,14+/m1/s1

Kī InChi:

QZECRCLSIGFCIO-RISCZKNCSA-N

Kupumatua:

AZD-5069, AZD5069, AZD 5069, 878385-84-3

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te AZD-5069 he kaitukino CXCR2 kaha me te whiriwhiri me te kaha ki te aukati i te heke o te neutrophil ki roto i nga huarahi rererangi i roto i nga turoro me te COPD. I whakaatuhia te AZD-5069 ki te aukati i te herenga o te radiolabeled CXCL8 ki te tangata CXCR2 me te uara pIC50 o 9.1. I tua atu, ka whakakorehia e te AZD5069 te chemotaxis neutrophil, me te pA2 tata ki te 9.6, me te whakahuatanga ngota adhesion, me te pA2 o 6.9, hei whakautu ki te CXCL1. Ko te AZD5069 he kaitukino puhoi whakamuri o CXCR2 me nga paanga o te waa me te pāmahana e kitea ana i runga i te rongoa rongoa me nga kinetika here. Ko te AZD-5069 ka whai hua ano mo te manawanui i roto i nga ahuatanga mumura.

Whāinga: CXCR2