Derazantinib; ARQ-087

Ingoa matū:

(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine

Waehere SMILES:

COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1

Waehere InChi:

InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24- 10-4-5-12-2 7(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H ,32,33,34)/t26-/m1/s1

Kī InChi:

KPJDVVCDVBFRMU-AREMUKBSSA-N

Kupumatua:

Derazantinib, ARQ-087, ARQ087, ARQ 087, 1234356-69-4

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko Derazantinib, e mohiotia ana ko ARQ-087, he aukati koiora-a-waha o te kaikawe fibroblast growth factor (FGFR) me te mahi antineoplastic pea. Ko te aukati FGFR ARQ 087 ka herea, ka kaha te aukati i te mahi o nga momo-iti FGFR 1, 2 me 3. Ka hua pea tenei ki te aukati i nga huarahi whakawhiti tohu tohu FGFR-whakawaenga, te tipu o te pukupuku pukupuku, te angiogenesis pukupuku me te mate pukupuku pukupuku i roto i te FGFR-overexpressing pūtau pukupuku. . Ko te FGFR, he kaikawe tyrosine kinase, he mea whakatikatika i roto i te maha o nga momo pūtau puku me te whai waahi nui ki te tipu o te pūtau puku, te rereketanga, te angiogenesis me te oranga.

Whāinga: FGFR