RGX-104 HCl

Ingoa matū:

(R)-2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid hydrochloride

Waehere SMILES:

O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl

Waehere InChi:

InChI=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31(33(28)35)34(36 ,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27;/h2-17,20,24,30H,18- 19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1

Kī InChi:

LCMIYQOJZLRHTO-GJFSDDNBSA-N

Kupumatua:

RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te RGX-104 he ate X receptor beta agonist me nga mahi immunomodulating me nga mahi antineoplastic. I runga i te whakahaere a-waha, ko te RGX-104 te tohu me te herea ki te LXRbeta, na reira ka whakahohe i te tohu-whakawaenga-a-LXRbeta, ka arahi ki te tuhi o etahi ira aukati puku me te whakahekenga o etahi ira kaiwhakatairanga puku. Ma tenei ka tino whakahoahohia te whakahuatanga o te apolipoprotein E (ApoE), he pūmua aukati puku, i roto i nga pūtau puku me etahi pūtau aukati. Ma tenei ka whakahoahohia te punaha mate a-roto, ka mutu te whakahekenga o nga pūtau suppressor immunosuppressive myeloid (MDSCs), nga pūtau puku me nga pūtau endothelial i roto i te microenvironment puku. Ma tenei ka huri i te aukati aukati, ka whakarei ake i nga urupare aukati anti-tumor me te aukati i te tipu o nga pūtau puku.

Whāinga: LXRbeta