NTN21277

Chemeschen Numm:

(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chlor-4-fluorphenyl)amino)-7-methoxyquinazolin-6-yl) oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidin-2-carboxamide

SMILES Code:

O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC )=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

InChi Code:

InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57) 26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64- 40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9- 14,21,23-24,27-28,33,38,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55, 58)(H,51,52,54)/t33-,38+,43-/m1/s1

InChi Schlëssel:

NICKHWYZMNLEPJ-TZSMONEZSA-N

Schlësselwuert:

Gefitinib-baséiert PROTAC 3; NTN21277; NTN-21277; NTN 21277

Solubilitéit: 

Stockage: 

Beschreiwung:

NTN21277, och bekannt als Gefitinib-baséiert PROTAC 3 ass e VHL-rekrutéierende PROTAC deen d'Degradatioun vun EGFR an EGFR Mutanten mat DC50 vun 11,7 nM an 22,3 nM fir HCCL827 Zell (Exon 19 del) an H3258R Zell (Exon 19 del) an H3258R Zell induzéiert.

Zil: EGFR