Tropifexor

Nomen chemicum:

2-((1R,3r,5S) -3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1] octan-8- yl) -4-fluorobenzo[d] thiazole-6-acidi carboxylic

SMILES Code:

FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C( C(O)=O)C=C7S6)[C@H](CC5)C4

InChi Code:

InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12- 18 (11-16) 39-13-20-24( 35-41-26(20)14-5-6-14) 19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14; 16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+

InChi Key:

VYLOOGHLKSNNEK-PIIMJCKOSA-N

Keyword:

Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2

Solubilitas:Solutum in DMSO

Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).

Descriptio:

Tropifexor (compositus 1) novus et altus potens agonista FXR cum EC50 0,2 nm. Robusta inductio generum tam BSEP quam SHP in primis cellulis a Tropifexore in modo concentratione dependens observatur. BSEP inductio supra vehiculum (DMSO) moderatio in concentratione tam infima quam 1 nM observatur, dum valida inductio SHP (15-plica supra vehiculum) observatur ad 10 nM et inductio modesta SHP ad 1 nM (3-ovili)[1 ].

Target: FXR