GLPG0187

Nomen chemicum:

(S) -3-((2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4- yl)amino)-2-((4-methoxyphenyl)sulfonamido)acidum propanoicum

SMILES Code:

O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5)=O

InChi Code:

InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23) 32-19(2)33-28(18)36-15-12-20(13-16-36)24-116-21-5-4-14-30-27(21)34-24/ h6-11,20,25,35H,4-5,12-17H2,1-3H3,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0 /s1

InChi Key:

CXHCNOMGODVIKB-VWLOTQADSA-N

Keyword:

GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1

Solubilitas:Solutum in DMSO

Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).

Descriptio:

In solido periodo GLPG0187 receptacula aliquot RGD integrina receptacula cum IC50s 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM pro αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 et α5β1. GLPG0187 inhibitor ossis osteoclasticae resorptionis et angiogenesis potens est. Curatio dosis dependenter cum GLPG0187 rationem E-cadherin/vimentin auget, cellulas reddit phaenotypum epithelialem, sessilium magis. GLPG0187 dosis dependenter diminuit aldehydae dehydrogenas magnitudinem altae subpopulation cellularum cancri prostatae [1]. Curatio GLPG0187 in cellulis rotunditatis et glebae resultat. GLPG0187 significat reductionem dosis dependens in migratione tumoris cellae. GLPG0187 ad omnes concentrationes significanter cellulam multiplicationem minuit[2].

Target: αvβ1