PQR530
Product Detail
Product Tags
| Pack Size | Availability | Pretium (USD) |
| 100mg | In Stock | 500 |
| 500mg | In Stock | 800 |
| 1g | In Stock | 1200 |
| Plus Sizes | Get Quotes | Get Quotes |
Nomen chemicum:
(S) -4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine
SMILES Code:
NC1=NC=C(C2=NC(N3[C@@H](C)COCC3)=NC(N4CCOCC4)=N2)C(C(F)F)=C1
InChi Code:
InChI=1S/C18H23F2N7O2/c1-11-10-29-7-4-27(11)18-24-16(13-9-22-14(21)8-12(13)15(19)20) 23-17(25-18)26-2-5-28-6-3-26/h8-9,11,15H,2-7,10H2,1H3,(H2,21,22)/t11-/m0 /s1
InChi Key:
SYKBZXMKAPICSO-NSHDSACASA-N
Keyword:
PQR530, PQR-530, PQR 530, 1927857-61-1
Solubilitas:Solutum in DMSO
Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).
Descriptio:
PQR530 inhibitor maxime potens est duplicem pan-PI3K/mTORC1/2. PQR530 interdum inhibitum kinasum B (PKB, pSer473) et interdum ribosomales S6 (pS6, pSer235/236) phosphorylationem cum valoribus IC50 0.07 µM. PQR530 egregiam selectionem praebuit in ampla tabula kinasium, necnon eximiam selectivity versus receptoris enzymes et canales ion finitimus. Potentia autem PQR530 in tabula lineae cellae 44 cancri (NTRC OncolinesTM) ostensa est ne incrementum cellae cancer (medii valoris pro GI50 426 nM). Applicatio oris PQR530 ad mures consecuta est in dose proportionalis PK et boni oris demonstrati bioavailability et cerebrum excellentis penetrationis.
Target: PI3K/mTOR
