ARS-1630

Nomen chemicum:

(R) -1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-unum

SMILES Code:

"C=CC(N1CCN(C2=C3C=C(Cl)C)[C@@]([C@@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1 )=O.[R]

InChi Code:

InChi Key:

Keyword:

ARS1630, ARS 1630, ARS-1630, 1698055-86-5

Solubilitas:Solutum in DMSO

Repono:0 - 4° C pro brevi termino (dies ad hebdomades), vel -20° C ad terminum longum (menses)

Descriptio:

ARS-1630 est R-conformationalis atropisomer ARS-1620, 1,000-trina potentior quam ARS-1620 (1.2 ± 0,6 M-1s-1) et sic agit ut singulare inactivum imperium compositum.

Target: KRAS (K-Ras G12C)