E-7046

Nomen chemicum:

(S) -4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)acidi benzoici

SMILES Code:

O=C(O)C1=CC=C([C@@H](NC(C2=C(OC3=CC=CC(C(F)F)(F)=C3)N(C)N=C2C (F)F)=O)C)C=C1

InChi Code:

InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30( 2)20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3(H,28,31)(H; 32,33)/t11-/m0/s1

InChi Key:

MKLKAQMPKHNQPR-NSHDSACASA-N

Keyword:

E-7046, E7046, E 7046, 1369489-71-3

Solubilitas:Solutum in DMSO

Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).

Descriptio:

In exemplari tumore CT-26, compositio E7046/RT causat responsionem anti-tumorem memoriae 9 animalium. In 4T1 exemplar, compositum ex E7046 et RT etiam melius significantes tumorem incrementi inhibitionis actionis comparatae cum unaquaque curatione producit. Compositio signanter meliorem superesset, inhibendo metastasim spontaneam pulmonem subsequentem tumorum 4T1[1]. E7046 (150 mg/kg) incrementum syngeneici multiplicatorum exemplorum vetat. Obsidio EP4 significationis anti-tumorem DC differentiationem promovet et incrementum in murium tumorem tardat. E7046 curatio incrementa vel etiam reiecta tumores vivos stabilitos reducit modo dependens ab cellulis tum myeloideis et CD8C T. Praeterea co-administratio E7046 et E7777, IL-2-diphtheria toxin fusionis interdum quae potiore Tregs necat, synergistice retiacula immunosuppressiva myeloid et Treg disrumpit, inde in responsionibus efficacibus et durabilibus anti-tumoris immunis in exemplaribus tumoris muris (2). .

Target: EP4