BI-847325

Aha kemịkalụ:

(Z) -3- (3- (((4- ((dimethylamino)methyl) phenyl)amino) (phenyl) methylene -2-oxoindolin-6-yl) -N-ethylpropiolamide

Koodu Ọchịchọ:

O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4

Koodu InChi:

InChi=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-22)31-23-14-10-21 (11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2, 1-3H3, (H,30,34)(H,32,35)/b28-27-

Igodo InChi:

FLBNLJLONKAPLR-DQSJHHFOSA-N

Okwu:

BI-847325, BI847325, BI 847325, 1207293-36-4

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

Nkọwa:

BI-847325 bụ nhọrọ abụọ MEK / Aurora kinase inhibitor nwere ụkpụrụ IC50 nke 3, 25, 15, 25, na 4 nM maka X. laevis Aurora B, mmadụ Aurora A na Aurora C, na mmadụ MEK1 na MEK2, n'otu n'otu. Ọ nwere ike igbochi uto na nlanarị nke ahịrị mkpụrụ ndụ melanoma na-adịghị ahụkebe na ọgwụ na-eguzogide ọgwụ, na-ebelata okwu MEK na Mcl-1 ebe ọ na-abawanye okwu pro-apoptotic protein Bim. Na 70 mg / kg, BI-847325 na-ebute apoptosis na ọgwụgwọ-naive na ọgwụ na-eguzogide xenografted melanoma na vivo.

Ebumnuche: MEK/Aurora