BLU-667
Nkọwa ngwaahịa
Mkpado ngwaahịa
Nha ngwugwu | Nnweta | Ọnụ ego (USD) |
Aha kemịkalụ:
(1s, 4R) -N ((S) -1- (4- (4-fluoro-1H-pyrasol-1-yl) phenyl) ethyl) -1-methoxy-4- (4-methyl-6-). (5-methyl-1H-pyrazol-3-yl) amino) pyrimidin-2-yl cyclohexane-1-carboxamide
Koodu Ọchịchọ:
CC1=NC([C@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3=O) (OC)CC2=NC(NC5=NNC(C)=C5)=C1
Koodu InChi:
InChi=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27 (38) 32-19 (3) 20-5 -7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13-16,19,21H,9-12H2,1-4H3,(H,32, 38) (H2,31,33,34,35,36)/t19-,21-,28+/m0/s1
Igodo InChi:
HUQPYQIGHTXBNW-BDHWGLMFSA-N
Okwu:
BLU-667; BLU 667; BLU667
Solubility:DMSO
Nchekwa:
Nkọwa:
BLU-667 bụ onye na-egbochi ike na nhọrọ nke mmụgharị RET, fusions na mutant na-eguzogide amụma. Njikọ RET bụ isi ihe na-akpata ọrịa cancer dị iche iche, gụnyere ngụgụ na ọrịa thyroid, na nyocha anyị na-egosi na RET na-ekerekwa òkè dị mkpa na ụfọdụ ọrịa cancer colon na ara. Site n'otu oge lekwasịrị anya na onye ọkwọ ụgbọ ala mbụ na mutant na-eguzogide amụma nke na-eme ka mkpụrụ ndụ kansa ghara inwe mmetụta na ọgwụgwọ ọgwụ akwadoro ugbu a,
Ebumnuche: RET