GSK2982772

Aha kemịkalụ:

(S) -5-Benzyl-N- (5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo [b]-[1,4] oxazepin-3-yl) -4H-1,2, 4-triazole-3-carboxamide

Koodu Ọchịchọ:

O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@@H]3C(N(C)C4=CC=CC=C4OC3)=O

Koodu InChi:

InChi=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23- 24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14 -/m0/s1

Igodo InChi:

LYPAFUINURXJSG-AWEZNQCLSA-N

Okwu:

GSK-2982772, GSK 2982772, GSK2982772, 1622848-92-3

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

GSK2982772 bụ onye nwere ike na nhọrọ nnabata Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate for the Treatment of Inflammatory Diseases. GSK2982772 dị ugbu a na ngalaba 2a ọmụmụ ụlọ ọgwụ maka psoriasis, ọrịa ogbu na nkwonkwo, na ulcerative colitis. GSK2982772 na-ejikọta RIP1 nke ọma na kinase nkọwapụta ma nwee ọmarịcha ọrụ na igbochi ọtụtụ nzaghachi ekwentị dabere na TNF. RIP1 apụtala dị ka kinase dị elu dị mkpa nke egosiri na-achịkwa mbufụt site na ma scaffolding na kinase kpọmkwem ọrụ.

Ebumnuche: RIP1