BAZ2-ICR

Aha kemịkalụ:

4- (4- (1-methyl-1H-pyrazol-4-yl) -1- (2- (1-methyl-1H-pyrazol-4-yl) ethyl) -1H-imidazol-5-yl) benzonitrile

Koodu Ọchịchọ:

CN(N=C1)C=C1C2=C(C3=CC=C(C#N)C=C3)N(CCC4=CN(C)N=C4)C=N2

Koodu InChi:

InChi=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24-26(2)13-18)20(27) 17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3

Igodo InChi:

RRZVGDGTWNQAPW-UHFFFAOYSA-N

Okwu:

BAZ2-ICR, BAZ2ICR, BAZ2 ICR, 1665195-94-7

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

BAZ2-ICR bụ ezigbo nyocha kemịkalụ maka ọmụmụ ọrụ nke BAZ2 bromodomains in vitro na in vivo. Bromodomain nwere protein BAZ2A/B na-arụ ọrụ dị mkpa na nhazigharị chromatin na nhazi nke RNA ndị na-abụghị koodu. BAZ2-ICR nwere IC50 (BAZ2A) = 130 nM; IC50 (BAZ2B) = 180 nM; logD = 1.05; solubility 25 mm (D2O) na F = 70%.

Ebumnuche: BAZ2