GDC-0077

Aha kemịkalụ:

(S) -2- ((2-- (S) -4- (difluoromethyl) -2-oxooxazolidin-3-yl) -5,6-dihydrobenzo [f] imidazo [1,2-d] [1,4] ]oxazepin-9-yl) amino) propanamide

Koodu Ọchịchọ:

C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1

Koodu InChi:

InChi=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11) 24)2 5-12 (15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26 )/t9-,12-/m0/s1

Igodo InChi:

SGEUNORSOZVTOL-CABZTGNLSA-N

Okwu:

GDC-0077, GDC0077, GDC 0077, 2060571-02-8

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

GDC-0077 bụ ihe dị n'ọnụ yana onye na-emechi PI3K (IC50 = 0.038 + 0.003 nM) yana> 300-fold ahọpụtara karịa isoforms Klas I PI3K ndị ọzọ. GDC-0077 na-arụ ọrụ ya site na ijikọ na saịtị njikọ ATP nke PI3K, si otú a na-egbochi phosphorylation nke PIP2 na PIP3.

Ebumnuche: PI3K