BLU-285

Aha kemịkalụ:

(S) -1- (4-fluorophenyl) -1- (2-- (4---6-- 1-methyl-1H-pyrazol-4-yl) pyrrolo [2,1-f] [1,2,4] ]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine

Koodu Ọchịchọ:

CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC= N3)=C2)=C1

Koodu InChi:

InChi=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35( 8-10-36)2 4-23-11-18 (16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2, 1-2H3/t26-/m0/s1

Igodo InChi:

DWYRIWUZIJHQKQ-SANMLTNESA-N

Okwu:

BLU-285, BLU 285, BLU285, Avapritinib

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

Avapritinib (BLU-285) egosipụtala ọrụ biochemical in vitro na KIT exon 17 mutant enzyme, KIT D816V (IC50=0.27 nM). A na-atụ ọrụ cellular nke Avapritinib na mutants KIT D816 site na autophosphorylation n'ime eriri cell mast cell leukemia cell HMC1.2, yana P815 mouse mastocytoma cell line na IC50 = 4 na 22 nM, n'otu n'otu. N'ime mkpụrụ ndụ Kasumi-1, na (8; 21) -ahịrị cell AML dị mma na KIT exon 17 N822K mutation, Avapritinib na-egbochi KIT N822K mutant autophosphorylation (IC50 = 40 nM), akara mgbada ala, yana mmụba cellular (IC50 = 75 nM)[1].

Ebumnuche: KIT