GLPG0187

Aha kemịkalụ:

(S) -3- ((2,5-dimethyl-6-- (4- (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl) piperidin-1-yl) pyrimidin-4- yl) amino)-2- ((4-methoxyphenyl) sulfonamido) propanoic acid.

Koodu Ọchịchọ:

O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5)=O

Koodu InChi:

InChi=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23) 32-19 (2) 33-28 (18)36-15-12-20 (13-16-36)24-11-6-21-5-4-14-30-27 (21)34-24/ h6-11,20,25,35H,4-5,12-17H2,1-3H3,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0 /s1

Igodo InChi:

CXHCNOMGODVIKB-VWLOTQADSA-N

Okwu:

GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

Na nyocha nke siri ike, GLPG0187 na-egosi nhọrọ maka ọtụtụ ndị na-anabata integrin RGD nwere IC50s nke 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM maka αvβ1, αvβ3, αvβ5, αvβ,6, αvβ8. GLPG0187 bụ ihe mgbochi siri ike nke resorption ọkpụkpụ osteoclastic na angiogenesis. Ọgwụgwọ na GLPG0187 dose-dabere na-abawanye nha E-cadherin/vimentin, na-eme ka mkpụrụ ndụ bụrụ epithelial karịa, phenotype sessile. GLPG0187 dose-dabere na-ebelata nha nke aldehyde dehydrogenase dị elu nke mkpụrụ ndụ kansa prostate[1]. Ọgwụgwọ GLPG0187 na-ebute mkpụkọ cell na mkpọkọta. GLPG0187 na-egosiputa mbelata dị ukwuu dabere na dose na mbugharị cell tumor. GLPG0187 na mkpokọta niile na-ebelata nke ọma mmụba cell[2].

Ebumnuche: αvβ1