RGX-104 HCl
Nkọwa ngwaahịa
Mkpado ngwaahịa
Nha ngwugwu | Nnweta | Ọnụ ego (USD) |
100mg | Dị na ngwaahịa | 500 |
500mg | Dị na ngwaahịa | 800 |
1g | Dị na ngwaahịa | 1200 |
Nha ndị ọzọ | Nweta Quotes | Nweta Quotes |
Aha kemịkalụ:
(R) -2-[3-[3-[[2-Chloro-3- (trifluoromethyl) benzyl] (2,2-diphenylethyl) amino]-3-methylpropoxy] phenyl] acetic acid hydrochloride.
Koodu Ọchịchọ:
O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl
Koodu InChi:
InChI=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31 (33 (28)35)34 (36,37)38)23-30 (26-11-4-2-5-12-26)27-13-6-3-7-14-27; /h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1
Igodo InChi:
LCMIYQOJZLRHTO-GJFSDDNBSA-N
Okwu:
RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1
Solubility:Soluble na DMSO
Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).
Nkọwa:
RGX-104 bụ onye na-anabata beta agonist nwere ike immunomodulating na antineoplastic. Mgbe nchịkwa ọnụ, RGX-104 na-ahọrọ ma jikọta na LXRbeta, si otú ahụ na-eme ka mgbasa ozi mgbasa ozi LXRbeta rụọ ọrụ, na-eduga na nsụgharị nke ụfọdụ mkpụrụ ndụ ihe na-egbochi tumor na mbelata nke ụfọdụ mkpụrụ ndụ ihe na-akwalite tumor. Nke a na-eme ka ngosipụta nke apolipoprotein E (ApoE), protein na-egbochi tumor, na mkpụrụ ndụ tumo na ụfọdụ mkpụrụ ndụ na-alụso ọrịa ọgụ. Nke a na-eme ka usoro ahụ ji alụso ọrịa ọgụ pụta, na-ebute mbelata nke immunosuppressive myeloid-derived suppressor cell (MDSCs), mkpụrụ ndụ tumo na mkpụrụ ndụ endothelial na microenvironment tumor. Nke a na-atụgharị mgbapụ ọgụ, na-eme ka nzaghachi mgbochi tumor na-egbochi mgbasa nke mkpụrụ ndụ tumo.
Ebumnuche: LXRbeta