OTS964

Aha kemịkalụ:

(R) -9- (4- (1- (dimethylamino) propan-2-yl) phenyl) -8-hydroxy-6-methylthieno [2,3-c] quinolin-4 (5H) -otu.

Koodu Ọchịchọ:

[H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3=C(O)C=C2C)C4=C1SC =C4

Koodu InChi:

InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22 (17)23 (27)24-21 (13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1

Igodo InChi:

YHPWOYBWUWSJDW-UQKRIMTDSA-N

Okwu:

OTS 964, OTS-964, OTS964, 1338545-07-5

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

Nkọwa:

OTS964 bụ onye na-egbochi lymphokine na-arụ ọrụ egbu egbu T cell sitere na protein kinase (TOPK; IC50 = 28 nM). Ọ na-egbochi cytokinesis kpọmkwem, na-eduga na apoptosis, n'ọtụtụ mkpụrụ ndụ cancer. OTS964 na-ebute apoptosis nke mkpụrụ ndụ kansa akpa ume mmadụ na xenografts òké.

Ebumnuche: TOPK