AZD7507

Aha kemịkalụ:

4- (2-fluoro-4-methylanilino) -6-[4- (2-hydroxyethyl) piperazin-1-yl] -7-methoxycinnoline-3-carboxamide

Koodu Ọchịchọ:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

Koodu InChi:

InChi=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31)20 (33-2)13-18 (15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2 ,25,32)(H,26,27)

Igodo InChi:

CPDGCAFPYOTGO-UHFFFAOYSA-N

Okwu:

AZD7507; AZD-7507; AZD 7507

Solubility:DMSO

Nchekwa: 

Nkọwa:

AZD7507 bụ onye nwere ike ma họrọ CSF-1R inhibitor (ọrụ cell 32 nM), a na-ewere AZD7507 dị ka onyinye na-ekwe nkwa ka ọ na-ejigide ikike achọrọ na akụrụngwa ọgwụ pharmacokinetic nke AZ683. Ọzọkwa, na nyocha nke telemetry na nkịta nyere otu ọgwụ ọnụ, ọ nweghị nsí nke obi, ọ dịghị elu nke troponin metụtara ọgwụgwọ ahụ, ọ dịghịkwa mgbanwe na ECG.

Ebumnuche: CSF-1R