BLU-9931

Aha kemịkalụ:

N- (2- ((6-- (2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino) -3-methylphenyl) acrylamide.

Koodu Ọchịchọ:

C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O

Koodu InChi:

InChi=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-) 17 (16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33) (H,29,31,32)

Igodo InChi:

TXEBNKKOLVBTFK-UHFFFAOYSA-N

Okwu:

BLU-9931, BLU9931, BLU 9931, 1538604-68-0

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

N'ime sel MDA-MB-453, BLU9931 na-egbochi phosphorylation nke ụzọ akara FGFR4. BLU9931 na-egbochi mmụba nke ahịrị sel HCC nke na-egosipụta mgbagwoju anya FGFR4 adịghị emebi emebi, dị ka ahịrị sel Hep 3B, HUH-7 na JHH-7, yana EC50 nke<1 μM. BLU9931 na-egbochikwa mmụba n'ahịrị cell ewepụtara PDX nwere ụzọ akara FGFR4 na-emebibeghị [1]. BLU9931 na-ebute mbelata akpụ n'ụdị carcinoma hepatocellular nke na-egosipụta ligand / ihe nnabata na-arụ ọrụ nke mejupụtara FGF19/FGFR4/KLB ma gbakwunye na ndepụta na-eto eto nke ndị na-emegide FGFR4.

Ebumnuche: FGFR4