MSC2530818

Inoa Kimia:

[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

SMILES Code:

O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3

Code InChi:

InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16 (23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/ m0/s1

Ki InChi:

ODRITQGYYWHQGM-INIZCTEOSA-N

Hua'ōlelo:

MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO MSC2530818 kahi mea hoʻokae CDK8 Potent, Selective, a me ka waha Bioavailable me CDK8 IC50 = 2.6 nM; wānana PK kanaka: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F > 75%. Hōʻike ʻo MSC2530818 i ke koho kinase maikaʻi loa, biochemical a me ka ikaika cellular, microsomal stability, a hiki ke loaʻa i ka waha. Hōʻike ʻo MSC2530818 i ka mana kūpono a me ke koho ʻana e holomua i ka preclinical in vivo efficacy a me nā haʻawina palekana.

Kuhikuhi: CDK