PQR530

Inoa Kimia:

(S)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl) pyridin-2-amine

SMILES Code:

NC1=NC=C(C2=NC(N3[C@@H](C)COCC3)=NC(N4CCOCC4)=N2)C(C(F)F)=C1

Code InChi:

InChI=1S/C18H23F2N7O2/c1-11-10-29-7-4-27(11)18-24-16(13-9-22-14(21)8-12(13)15(19)20) 23-17(25-18)26-2-5-28-6-3-26/h8-9,11,15H,2-7,10H2,1H3,(H2,21,22)/t11-/m0 /s1

Ki InChi:

SYKBZXMKAPICSO-NSHDSACASA-N

Hua'ōlelo:

PQR530, PQR-530, PQR 530, 1927857-61-1

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO PQR530 kahi mea hoʻopaneʻe pan-PI3K/mTORC1/2 ikaika loa. PQR530 inhibited protein kinase B (PKB, pSer473) a me ribosomal protein S6 (pS6, pSer235/236) phosphorylation me IC50 waiwai o 0.07 µM. Ua hōʻike ʻo PQR530 i ka koho maikaʻi loa ma luna o kahi papa ākea o nā kinases, a me ka koho maikaʻi loa me nā enzymes receptor pili ʻole a me nā kaila ion. Eia kekahi, ua hōʻike ʻo PQR530 i ka mana i loko o kahi papa o 44 mau laina maʻi maʻi (NTRC OncolinesTM) e pale i ka ulu ʻana o ka maʻi maʻi (ke kumu waiwai no GI50 o 426 nM). ʻO ka noi waha o PQR530 i nā ʻiole i loaʻa i kahi PK hoʻohālikelike a hōʻike i ka bioavailability waha maikaʻi a me ke komo ʻana o ka lolo.

Kuhikuhi: PI3K/mTOR